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( A ) Volcano plot depicting changes in the distribution of significance and fold change of identified proteins between control mice treated with vehicle (Veh) and semaglutide (Sema)
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The FDA’s formal guidance against compounded semaglutide — projected to eliminate USD 3.6 billion in compounding pharmacy and telehealth revenue in 2025–2026 — creates disruption risk for approximately 1.5 million patients receiving compounded GLP-1 outside branded channels
